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专利名称：Improved methods for the acylation of
maytansinol
发明人：Widdison, Wayne C.,Zhao, Robert Yongxin申请号：AU2018201392申请日：20180227公开号：AU2018201392A1公开日：20180315
摘要：#$%^&*AU2018201392A120180315.pdf##### I:
\\sxd\\Interwoven\\NRPortbl\\DCC\\SXD\\16504232_l.docx-2I 02 2018 ABSTRACT R2 0 % 00>__NH MeO N N - O MeO HO H Disclosed is a method of preparing an amino acid esterof maytansinol represented by the following formula by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also
disclosed is an improved method of preparing an amino acid ester of maytansinol in whicha nucleophile is added to the reaction mixture after completion of the reaction betweenmaytansinol and an N-carboxyanhydride of an amino acid.
申请人：ImmunoGen, Inc.
代理人：Davies Collison Cave Pty Ltd
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