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专利名称：Process for producing a concentrate
enriched in coagulation factors VII and VIIa
发明人：Nazreen Pancham申请号：US06/660762申请日：19841015公开号：US04637932A公开日：19870120
摘要：There is disclosed an improved process for producing a concentrate containingcoagulation factors VII and VIIa in relatively high purity by contacting an aqueouspreparation containing factors VII and VIIa with a divalent metal salt adsorbent havingselective affinity for calcium- binding coagulation factors and eluting the coagulationfactors therefrom, and contacting the eluate with an anionic exchange resin and
selectively eluting coagulation factors VII and VIIa therefrom by step or gradient elutiontechniques to obtain factors VII and VIIa in high yield, free of other coagulation factorsand other proteins. In one embodiment of this invention Cohn Effluent I may be used asthe source of factors VII and VIIa.
申请人：MILES LABORATORIES, INC.
代理人：Pamela A. Simonton
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