专利内容由知识产权出版社提供
专利名称：COMPOSITIONS AND METHODS FOR THE
PREPARATION OF PROTEASE RESISTANTHUMAN GROWTH HORMONEGLYCOSYLATION MUTANTS
发明人：Shawn DeFrees申请号：US11910958申请日：20060410
公开号：US20090124544A1公开日：20090514
摘要：The present invention relates to protease resistant mutants of human growthhormone, which contain newly introduced proteolysis resistant mutations and N-linked orO-linked glycosylation site(s), such that these recombinantly produced polypeptideshave glycosylation patterns distinctly different from that of the naturally occurringhuman growth hormone. The polynucleotide coding sequences for the mutants,
expression cassettes comprising the coding sequences, cells expressing the mutants, andmethods for producing the mutants are also disclosed. Further disclosed are
pharmaceutical compositions comprising the mutants and method for using the mutants.
申请人：Shawn DeFrees
地址：North Wales PA US
国籍：US
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